Carlos León Sobrino Post-doctoral Researcher

I am Carlos, and I work as a post-doc in the SEM group developing an iterative CRISPR-Cas based screening tool in Pseudomonas, with the aim of identifying targets for genome engineering and constructing improved strains for bioproduction.

About Me

I studied Biology at the University of Oviedo (Spain), specializing in Biochemistry and Molecular Biology. After finishing my degree, I got a grant to study at the Danish Archaea Centre, University of Copenhagen (Denmark), where I obtained a Ph.D. in 2015. During these years I studied virus-host interactions of the hyperthermophilic Sulfolobus islandicus and its fusiform virus STSV2, with a focus on the CRISPR-Cas response and generation of immunity. After graduating, I worked three years as a post-doc at the Centre for Microbial Ecology and Genomics, at the University of Pretoria (South Africa). There, I applied metatranscriptomics to study microbial communities of the Namib Desert soils, an ecosystem on the arid limits of biological activity that is heavily dependent on rare and short pulses of rain water. It was a personally and professionally enriching experience for me, as I enjoyed a lot of freedom and responsibility over design and analysis. In 2019, I received a Villum Foundation Experiment grant to join Pablo’s team at DTU Biosustain and embark on an exciting project that draws from my past experience with natural CRISPR-Cas systems and population dynamics.